GWC may refer to:

• Dutch West India Company (Dutch: Geoctroyeerde Westindische Compagnie)
• Gambian Workers' Confederation, a Gambian trade union
• General Watch Co, a defunct Swiss watchmaker
• George Watson's College, in Edinburgh, Scotland
• George Whitefield College, in Cape Town, South Africa
• George Wythe College, now George Wythe University, in Salt Lake City, Utah, United States
• Global Water Challenge, a water resource charity
• Global Wildlife Center, a conservation charity
• Gnome Wave Cleaner, audio software
• Golden West College, in Huntington Beach, California, United States
• Golden West Colleges, in the Philippines
• Government Wine Cellar, of the government of the United Kingdom
• Great West Conference, an American college athletic conference
• The Great Western Chorus of Bristol, a British choir
• Green–white–checker finish, a procedure in North American auto racing
• Green Worker Cooperatives, a worker cooperative incubator in New York City
• Kalami language, spoken in Pakistan